CORNERSTONES

The key points underlying the activities of the Research Center are:

  • Without losing their excellent short- and long-term outcomes, cardiac surgeons are ready to target new measures of outcomes that are related to patient’s satisfaction and QoL. A multidisciplinary approach from surgeons, anesthesiologists, perfusionists, nurses and physical therapists may help reducing the impact of our interventions by reducing physical and psychological trauma, fastening recovery with enhanced post-operative lifestyle.
  • The development of simplified techniques is crucial for MICS dissemination within a surgical team/community.
  • Cardiac surgeons should embrace catheter-based techniques and technologies in theirs and their patients’ interest.

Our Research Center is at work to generate the evidence at support of the above-mentioned notions.

https://www.minicardiacsurgery-univpm-research.com/wp-content/uploads/2021/03/CORNERSTONES-new.png
https://www.minicardiacsurgery-univpm-research.com/wp-content/uploads/2021/04/SURGICAL-HYBRID-AND-TRANS-CATHETER-ACTIVITY-new2.png

SURGICAL, HYBRID AND TRANS-CATHETER ACTIVITIES

MICS – Minimally Invasive Cardiac Surgery (MICS)

  • 360° Minimally Invasive Cardiac Surgery (Mini incisions, Minimally invasive extracorporeal circulation, Sutureless and Rapid Deployment valves, Ultra-fast track anesthesia)
  • Trans axillary direct view mini mitral valve repair
  • Minimally Invasive Extracorporeal Circulation (MiECC)

Catheter based

  • Trans-catheter aortic and mitral valve interventions in cardiac surgery (TAVI, Clip and TMVR)
  • Aortic arch endovascular repair

Hybrid

  • Catheter-based cerebral protection in cardiac surgery (percutaneous embolic filters)
  • Arch replacement with frozen elephant trunk without hypothermic circulatory arrest (hybrid)
  • Development of new aortic arch grafts

SURGICAL, HYBRID AND TRANS-CATHETER ACTIVITIES

MICS – Minimally Invasive Cardiac Surgery (MICS)

  • 360° Minimally Invasive Cardiac Surgery (Mini incisions, Minimally invasive extracorporeal circulation, Sutureless and Rapid Deployment valves, Ultra-fast track anesthesia)
  • Trans axillary direct view mini mitral valve repair
  • Minimally Invasive Extracorporeal Circulation (MiECC)

Catheter based

  • Trans-catheter aortic and mitral valve interventions in cardiac surgery (TAVI, Clip and TMVR)
  • Aortic arch endovascular repair

Hybrid

  • Catheter-based cerebral protection in cardiac surgery (percutaneous embolic filters)
  • Arch replacement with frozen elephant trunk without hypothermic circulatory arrest (hybrid)
  • Development of new aortic arch grafts
https://www.minicardiacsurgery-univpm-research.com/wp-content/uploads/2021/04/SURGICAL-HYBRID-AND-TRANS-CATHETER-ACTIVITY-new2.png

CURRENT RESEARCH PROJECTS

ESP4VI – An innovative Engineering-Supported functional Planning methodology for trans-catheter aortic Valve Implantation.

A multidisciplinary project involving cardiac surgeons performing either surgical aortic valve replacement (SAVR), Transcatheter Aortic Valve Replacement (TAVR) and Valve in Valve (ViV) and engineers having experience on experimental and computational modelling, aiming to create experimental setups and validate computational models for functional testing of SAVR, TAVR and ViV both in optimal and suboptimal valve deployment configurations. Findings from this project will eventually support the development of TAVR and ViV implantation innovative planning methodologies and tools that, based on patient’s preoperative imaging, will not limit to predict the anatomical deployment of the valve but extend to calculate -and thus forecast- its functional behavior with a patient-tailored approach.

Cost-effectiveness and patient satisfaction analysis in minimally invasive valve surgery.

Multidisciplinary prospective observational study assessing clinical outcomes, cost sustainability, quality of life and patients’ satisfaction in patients undergoing minimally invasive vs. conventional valve surgery. This project is intended to provide additional elements of assessment of modern minimally invasive surgery not only to health professionals, but also to policy-makers, administrators and all those involved in public health management.

The Sutureless and Rapid- Deployment Aortic Valve Replacement International Registry (SURD-IR).

SURD-IR is an independent international registry established in 2015 by a consortium of international research centers— the International Valvular Surgery Study Group (IVSSG)—with the aim to evaluate the current management and outcomes of sutureless and rapid deployment aortic valve replacement (SURD-AVR). Currently, with over 5000 patients enrolled at 19 centers in Europe, Canada and Australia, SURD-IR is the largest worldwide registry on SURD-AVR.

Mini-Mitral International Registry (Mini-Mitral-IR).

An international independent retrospective/prospective registry assessing short- and long-term outcomes following minimally invasive mitral valve interventions. The Registry includes large referral centers with extensive experience in mini-mitral surgery. The main goal is that of generating, independent from industries, benchmark results for ongoing and future surgical and catheter based mitral valve interventions.

ERAS-MITRAL – A Multidisciplinary Enhanced Recovery Approach to Optimize Outcomes in Mitral Valve Surgery

ERAS-MITRAL is a multidisciplinary research project involving cardiac surgeons, anesthesiologists, intensivists, physiotherapists, psychologists, and data scientists, with the aim of evaluating the impact of an ultra-fast-track Enhanced Recovery After Surgery (ERAS) protocol in patients undergoing mitral valve repair or replacement.
The project compares a fully integrated ERAS pathway with conventional perioperative management, assessing clinical, functional, and psychological aspects of postoperative recovery. Key outcomes include early complications, length of hospital stay, recovery timelines, and emotional well-being.
The anticipated findings are expected to provide evidence on the value of an ERAS-based, patient-centred approach tailored to mitral valve surgery, demonstrating how coordinated perioperative care can improve the operative experience, shorten hospitalisation, and promote faster return to daily life. Ultimately, ERAS-MITRAL aims to support a shift toward more efficient, personalised, and recovery-oriented cardiac surgical care.

PUBLICATIONS

Minimally Invasive Cardiac Surgery and Enhanced Recovery After Surgery:

  1. Surgical techniques and outcomes for atrial functional mitral regurgitation: Insights from the mini mitral international registry. Berretta P, Nakamura M, Fiore A, Lamelas J, Bonaros N, Kempfert J, Salvador L, Gerdisch M, Van Praet F, Pitsis A, Yan T, Malvindi PG, Stefano P, Wilbring M, Doenst T, Pacini D, Dinh NH, Rinaldi M, Nguyen TC, Di Eusanio M. Eur J Cardiothorac Surg. 2025 Dec 3:ezaf438. doi: 10.1093/ejcts/ezaf438. Epub ahead of print. PMID: 41339275.
  2. Simplified approach for minimally invasive mitral valve surgery through a trans-axillary mini-thoracotomy access. Malvindi PG, Bifulco O, Spagnolo F, Galeazzi M, Berretta P, Cefarelli M, Wilbring M, Zingaro C, Kappert U, Di Eusanio M. Ann Thorac Surg. 2025 Nov 17:S0003-4975(25)01113-0. doi: 10.1016/j.athoracsur.2025.10.037. Epub ahead of print. PMID: 41260487.
  3. Endo-Aortic Balloon Occlusion versus Transthoracic Clamping in Minimally Invasive Mitral Valve Surgery. Kofler M, Berretta P, Bonaros N, Cresce GD, Rinaldi M, Pitsis A, Nguyen TC, Doenst T, Wilbring M, Gerdisch M, Lamelas J, Van Praet F, Yan T, Pacini D, Fiore A, Dinh NH, Stefano P, Kempfert J, Di Eusanio M. Eur J Cardiothorac Surg. 2025 Sep 1;67(9):ezaf258.
  4. Second cross-clamp in less invasive mitral valve repair for degenerative mitral regurgitation: Predictors and outcomes. Berretta P, Doenst T, Rinaldi M, Kempfert J, Lamelas J, Gerdisch M, Van Praet F, Pitsis A, Fiore A, Malvindi PG, Wilbring M, Dinh NH, Pacini D, Cresce GD, Bonaros N, Stefano P, Yan T, Nguyen TC, Di Eusanio M. J Thorac Cardiovasc Surg. 2025 Jul 28:S0022-5223(25)00638-5.
  5. Surgical decision-making for concomitant tricuspid valve repair in minimally invasive mitral valve surgery. Gollmann-Tepeköylü C, Berretta P, Gerdisch M, Cresce GD, Kempfert J, Pitsis A, Van Praet F, Rinaldi M, Wilbring M, Yan T, Pacini D, Doenst T, Fiore A, Dinh NH, Lamelas J, Stefano P, Nguyen TC, Bonaros N, Di Eusanio M. Eur J Cardiothorac Surg. 2025 Jul 1;67(7):ezaf201.
  6. The 10 Commandments of On-Table Extubation After Cardiac Surgery: Why and How to Increase Adoption. Malvindi PG, Berretta P, Munch C, Di Eusanio M.  Innovations (Phila). 2025 Jul-Aug;20(4):323-330.
  7. Minimally Invasive Mitral Valve Repair With New-Generation Annuloplasty Ring: Results From the International Prospective MANTRA Study. Hysi I, Di Eusanio M, Choi YH, Bonaros N, Kempfert J, Baeza C, Troise G, Pacini D, Pollari F, Santarpino G, Argano V, Badano L, Dzemali O. Innovations (Phila). 2025 May-Jun;20(3):283-289.
  8. Chirurgia dell’aorta ascendente e radice aortica con approccio mini-invasivo: la nostra esperienza [Minimally invasive thoracic aortic surgery: our experience]. Bifulco O, Berretta P, D’Alessio S, Giusti M, Capestro F, D’Alfonso A, Malvindi PG, Di Eusanio M. G Ital Cardiol (Rome). 2025 Mar;26(3):205-210. Italian.
  9. Telemedicine/Telerehabilitation to Expand Enhanced Recovery After Surgery Interventions in Minimally Invasive Mitral Valve Surgery. Malvindi PG, Ceravolo MG, Capecci M, Balestra S, Cinì E, Antoniello A, Pepa L, Carbonetti A, Ricci M, Berretta P, Mazzocca F, Fioretti M, Volpe U, Munch C, Di Eusanio M. J Clin Med. 2025 Jan 24;14(3):750.
  10. Chirurgia mini-invasiva per via trans-ascellare e gestione “ultra-fast-track”: un nuovo paradigma per il trattamento della patologia mitralica [Minimally invasive trans-axillary approach and ultra-fast-track management: a new paradigm for mitral valve disease treatment]. Bifulco O, Malvindi PG, Berretta P, Galeazzi M, Spagnolo F, Cefarelli M, Alfonsi J, D’Alfonso A, Capestro F, Zingaro C, Di Eusanio M. G Ital Cardiol (Rome). 2025 Jan;26(1):61-67. Italian.
  11. The transaxillary concept for minimally invasive isolated aortic valve replacement: results of 1000 consecutive patients. Wilbring M, Arzt S, Taghizadeh-Waghefi A, Petrov A, Di Eusanio M, Matschke K, Alexiou K, Kappert U. Eur J Cardiothorac Surg. 2024 Nov 28;66(6):ezae427.
  12. Impact of Complex Anatomy and Patient Risk Profile in Minimally Invasive Mitral Valve Surgery. Berretta P, Pitsis A, Bonaros N, Kempfert J, Wilbring M, Stefano P, Van Praet F, Lamelas J, Malvindi PG, Gerdisch M, Pacini D, Yan T, Rinaldi M, Salvador L, Fiore A, Doenst T, Dinh NH, Nguyen TC, Di Eusanio M. Ann Thorac Surg. 2025 Jan;119(1):137-144.
  13. The Enhanced Recovery after Surgery Approach in Heart Valve Surgery: A Systematic Review of Clinical Studies. Malvindi PG, Bifulco O, Berretta P, Galeazzi M, Alfonsi J, Cefarelli M, Zingaro C, Zahedi HM, Munch C, Di Eusanio M. J Clin Med. 2024 May 14;13(10):2903.
  14. Pacemaker implantation after concomitant tricuspid valve repair in patients undergoing minimally invasive mitral valve surgery: Results from the Mini-Mitral International Registry. Faerber G, Berretta P, Nguyen TC, Wilbring M, Lamelas J, Stefano P, Kempfert J, Rinaldi M, Pacini D, Pitsis A, Gerdisch M, Dinh NH, Van Praet F, Salvador L, Yan T, Bonaros N, Fiore A, Doenst T, Di Eusanio M. JTCVS Open. 2023 Nov 19;17:64-71.
  15. Minimally Invasive Trans-Axillary versus Full Sternotomy Mitral Valve Repair: A Propensity Score-Matched Analysis on Mid-Term Outcomes. Bifulco O, Malvindi PG, Berretta P, Brugiatelli L, Cefarelli M, Alfonsi J, D’Alfonso A, Zingaro C, Di Eusanio M. Medicina (Kaunas). 2023 Dec 23;60(1):29.
  16. On-table extubation is associated with reduced intensive care unit stay and hospitalization after trans-axillary minimally invasive mitral valve surgery. Malvindi PG, Bifulco O, Berretta P, Galeazzi M, Zingaro C, D’Alfonso A, Zahedi HM, Munch C, Di Eusanio M. Eur J Cardiothorac Surg. 2024 Mar 1;65(3):ezae010.
  17. Neurological outcomes in minimally invasive mitral valve surgery: risk factors analysis from the Mini-Mitral International Registry. Cresce GD, Berretta P, Fiore A, Wilbring M, Gerdisch M, Pitsis A, Rinaldi M, Bonaros N, Kempfert J, Yan T, Van Praet F, Nguyen HD, Savini C, Lamelas J, Nguyen TC, Stefano P, Färber G, Salvador L, Di Eusanio M. Eur J Cardiothorac Surg. 2023 Oct 4;64(4):ezad336.
  18. Transaxillary approach enhances postoperative recovery after mitral valve surgery. Malvindi PG, Wilbring M, De Angelis V, Bifulco O, Berretta P, Kappert U, Di Eusanio M. Eur J Cardiothorac Surg. 2023 Jul 3;64(1):ezad207.
  19. Aortic cross-clamp time correlates with mortality in the mini-mitral international registry. Doenst T, Berretta P, Bonaros N, Savini C, Pitsis A, Wilbring M, Gerdisch M, Kempfert J, Rinaldi M, Folliguet T, Yan T, Stefano P, Van Praet F, Salvador L, Lamelas J, Nguyen TC, Dinh NH, Färber G, Di Eusanio M. Eur J Cardiothorac Surg. 2023 Jun 1;63(6):ezad147.
  20. Risk-related clinical outcomes after minimally invasive mitral valve surgery: insights from the Mini-Mitral International Registry. Berretta P, Kempfert J, Van Praet F, Salvador L, Lamelas J, Nguyen TC, Wilbring M, Gerdisch M, Rinaldi M, Bonaros N, Folliguet T, Doenst T, Nguyen DH, Stefano P, Yan T, Savini C, Pitsis A, Di Eusanio M. Eur J Cardiothorac Surg. 2023 Jun 1;63(6):ezad090.
  21. del Nido and Histidine-Tryptophan-Ketoglutarate cardioplegia in minimally invasive mitral valve surgery: A propensity-Match study. Malvindi PG, Bifulco O, Berretta P, Silvano R, Alfonsi J, Cefarelli M, Zingaro C, Di Eusanio M. Perfusion. 2024 May;39(4):823-832.
  22. Comparison of minimally invasive versus conventional thoracic aortic operations: Early and midterm results in a series of 624 patients. Berretta P, Chiuselli G, Galeazzi M, Codecasa R, Alfonsi J, Braconi L, Bifulco O, Rapisarda F, Malvindi PG, Bonacchi M, Stefano P, Di Eusanio M. J Card Surg. 2022 Dec;37(12):4732-4739.
  23. Enhanced recovery after minimally invasive heart valve surgery: Early and midterm outcomes. Berretta P, De Angelis V, Alfonsi J, Pierri MD, Malvindi PG, Zahedi HM, Munch C, Di Eusanio M. Int J Cardiol. 2023 Jan 1;370:98-104.
  24. Minimally invasive approach: is this the future of aortic surgery? Berretta P, Galeazzi M, Cefarelli M, Alfonsi J, De Angelis V, Pierri MD, Matteucci SML, Alessandroni E, Zingaro C, Capestro F, D’Alfonso A, Di Eusanio M. Indian J Thorac Cardiovasc Surg. 2022 Apr;38(Suppl 1):171-182.
  25. Minimally Invasive Mitral Valve Surgery After Transcatheter Edge-to-Edge Repair. Pizano A, Riojas R, Ailawadi G, Smith RL, George T, Gerdisch MW, Di Eusanio M, Castillo-Sang M, Ramlawi B, Rodriguez E, Morse MA, Doolabh NS, Jessen ME, Wei L, Chu MWA, Berretta P, Cura Stura E, Salizzoni S, Rinaldi M, Kaneko T, Tang GHL, Chikwe J, Roach A, Trento A, Badhwar V, Nguyen TC. Innovations (Phila). 2022 Jan-Feb;17(1):42-49.
  26. Surgery without Scars: Right Lateral Access for Minimally Invasive Aortic Valve Replacement. Wilbring M, Matschke KE, Alexiou K, Di Eusanio M, Kappert U. Thorac Cardiovasc Surg. 2021 Aug;69(5):461-465.
  27. Ultra fast-track trans-axillary mini-aortic valve replacement. Di Eusanio M, Alfonsi J, Berretta P, Zahedi H, Pierri MD, Cefarelli M. Ann Cardiothorac Surg. 2020 Sep;9(5):427-428.
  28. Aortic valve replacement using stented or sutureless/rapid deployment prosthesis via either full-sternotomy or a minimally invasive approach: a network meta-analysis. Woldendorp K, Doyle MP, Bannon PG, Misfeld M, Yan TD, Santarpino G, Berretta P, Di Eusanio M, Meuris B, Cerillo AG, Stefàno P, Marchionni N, Olive JK, Nguyen TC, Solinas M, Bianchi G. Ann Cardiothorac Surg. 2020 Sep;9(5):347-363.
  29. Right Lateral Access for Minimally Invasive Aortic Valve Replacement. Wilbring M, Matschke KE, Alexiou K, Di Eusanio M, Kappert U. Surgery without Scars: Thorac Cardiovasc Surg. 2020 Oct 19.
  30. Minimally Invasive Vs. Conventional Aortic Valve Replacement With Rapid-Deployment Bioprostheses. D’Onofrio A, Tessari C, Lorenzoni G, Cibin G, Martinelli GL, Alamanni F, Polvani G, Solinas M, Massetti M, Merlo M, Vendramin I, Di Eusanio M, Mignosa C, Mangino D, Russo C, Rinaldi M, Pacini D, Salvador L, Antona C, Maselli D, De Paulis R, Luzi G, Alfieri O, De Filippo CM, Portoghese M, Musumeci F, Colli A, Gregori D, Gerosa G. Ann Thorac Surg. 2020 Oct 8:S0003-4975(20)31630-1.
  31. Minimally invasive access type related to outcomes of sutureless and rapid deployment valves. Andreas M, Berretta P, Solinas M, Santarpino G, Kappert U, Fiore A, Glauber M, Misfeld M, Savini C, Mikus E, Villa E, Phan K, Fischlein T, Meuris B, Martinelli G, Teoh K, Mignosa C, Shrestha M, Carrel TP, Yan T, Laufer G, Di Eusanio M. Eur J Cardiothorac Surg. 2020 Nov 1;58(5):1063-1071.
  32. Minimally invasive aortic valve replacement: extracorporeal circulation optimization and minimally invasive extracorporeal circulation system evolution. Carozza R., Fazzi D., Pietrini A., Cefarelli M., Mazzocca F., Vessella W., Berretta P., Romagnoli M., Alfonsi J., Zahedi H. M., Munch C., Di Eusanio M. (2020). PERFUSION-UK.
  33. Minimally invasive versus standard extracorporeal circulation system in minimally invasive aortic valve surgery: a propensity score-matched study. Berretta P., Cefarelli M., Montecchiani L., Alfonsi J., Vessella W., Zahedi M. H., Carozza R., Munch C., Di Eusanio M. (2020). EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, vol. 57, p. 717-723.
  34. Surgical treatment of aortic valve disease: early results of a 360° minimally invasive approach. Di Eusanio M, Berretta P, Alfonsi J, Pierri MD, Zingaro C, Capestro F, D’Alfonso A, Fazzi D, Raffaeli V, Munch C, Vessella W, Cefarelli M. G Ital Cardiol (Rome). 2019 Sep;20(9):523-528.
  35. One-year outcomes of surgical aortic valve replacement: A single, high-volume center experience. Berretta P., Cefarelli M., Alfonsi J., Montecchiani L., Pierri M. D., Munch C., Di Eusanio M. (2020). GIORNALE ITALIANO DI CARDIOLOGIA, vol. 21, p. 216-223
  36. Endoscopic vein-graft harvesting in coronary artery bypass surgery: Tips and tricks. Zingaro C., Cefarelli M., Berretta P., Matteucci S., Pierri M., Di Eusanio M. MULTIMEDIA MANUAL OF CARDIOTHORACIC SURGERY 2019;
  37. Mini Bentall operation: technical considerations. Di Eusanio M., Cefarelli M., Zingaro C., Capestro F., Matteucci S. M. L., D’alfonso A., et al. INDIAN JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2019;35:87–91.
  38. Ultra fast-track minimally invasive aortic valve replacement: going beyond reduced incisions. Di Eusanio Marco, Vessella Walter, Carozza Roberto, Capestro Filippo, D’Alfonso Alessandro, Zingaro Carlo, et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 2018;
  39. Early and Mid-Term Results of Rapid Deployment Valves: The Intuity Italian Registry (INTU-ITA). D’Onofrio Augusto, Tessari Chiara, Filippini Claudia, Bagozzi Lorenzo, Diena Marco, Alamanni Francesco, et al. ANNALS OF THORACIC SURGERY 2018;106:1742-1749–1749.
  40. Minimally invasive reoperative aortic valve replacement: a systematic review and meta-analysis. Phan Kevin, Zhou Jessie J, Niranjan Nithya, Di Eusanio Marco, Yan Tristan D. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:15–25.
  41. Ministernotomy or minithoracotomy for minimally invasive aortic valve replacement: a Bayesian network meta-analysis. Phan Kevin, Xie Ashleigh, Tsai Yi-Chin, Black Deborah, Di Eusanio Marco, Yan Tristan D. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:3–14.
  42. Minimally invasive root surgery: a Bentall procedure through a J-ministernotomy. Di Eusanio M, Castrovinci S.,Cefarelli M.,Berretta P.,Alfonsi J.,Murana G., et al. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:198–200.
  43. Minimally invasive aortic valve replacement. Di Eusanio Marco. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:1–2.
  44. A meta-analysis of minimally invasive versus conventional sternotomy for aortic valve replacement. Phan Kevin, Xie Ashleigh, Di Eusanio Marco, Yan Tristan D. ANNALS OF THORACIC SURGERY 2014;98:1499–511.

Sutureless and Rapid Deployment International Registry:

  1. Sutureless versus transcatheter valves in patients with aortic stenosis at intermediate risk: A multi-institutional European study. Muneretto C, Di Bacco L, Pollari F, Baudo M, Solinas M, D’Alonzo M, Di Eusanio M, Rosati F, Folliguet T, Fischlein T. Surgery. 2023 Nov;174(5):1153-1160.
  2. Sutureless and Rapid Deployment vs. Transcatheter Valves for Aortic Stenosis in Low-Risk Patients: Mid-Term Results. Muneretto C, Di Bacco L, Di Eusanio M, Folliguet T, Rosati F, D’Alonzo M, Cugola D, Curello S, Palacios CM, Baudo M, Pollari F, Fischlein T. J Clin Med. 2023 Jun 14;12(12):4045.
  3. Pacemaker after Sutureless and Rapid-Deployment Prostheses: A Progress Report from the SURD-IR. Pollari F, Berretta P, Albertini A, Carrel T, Teoh K, Meuris B, Villa E, Kappert U, Andreas M, Solinas M, Misfeld M, Savini C, Fiore A, Shrestha M, Santarpino G, Martinelli GL, Mignosa C, Glauber M, Yan T, Fischlein T, Di Eusanio M. Thorac Cardiovasc Surg. 2023 Oct;71(7):557-565.
  4. Sutureless and rapid deployment versus sutured aortic valve replacement: a propensity-matched comparison from the Sutureless and Rapid Deployment International Registry. Berretta P, Andreas M, Meuris B, Langenaeken T, Solinas M, Concistrè G, Kappert U, Arzt S, Santarpino G, Nicoletti A, Misfeld M, Borger MA, Savini C, Gliozzi G, Albertini A, Mikus E, Fischlein T, Kalisnik J, Martinelli GL, Cotroneo A, Mignosa C, Ricasoli A, Yan T, Laufer G, Di Eusanio M. Eur J Cardiothorac Surg. 2022 Jul 11;62(2):ezac378.
  5. Surgical treatment of infective endocarditis: is there a role for rapid deployment aortic valve replacement? Berretta P, Malvindi PG, Alfonsi J, Di Eusanio M. Eur J Cardiothorac Surg. 2022 May 2;61(5):1116-1117.
  6. Sutureless Versus Rapid Deployment Aortic Valve Replacement: Results From a Multicenter Registry. Berretta P, Meuris B, Kappert U, Andreas M, Fiore A, Solinas M, Misfeld M, Carrel TP, Villa E, Savini C, Santarpino G, Teoh K, Albertini A, Fischlein T, Martinelli G, Mignosa C, Glauber M, Shrestha M, Laufer G, Phan K, Yan T, Di Eusanio M. Ann Thorac Surg. 2022 Sep;114(3):758-765.
  7. Aortic valve replacement using stented or sutureless/rapid deployment prosthesis via either full-sternotomy or a minimally invasive approach: a network meta-analysis. Woldendorp K, Doyle MP, Bannon PG, Misfeld M, Yan TD, Santarpino G, Berretta P, Di Eusanio M, Meuris B, Cerillo AG, Stefàno P, Marchionni N, Olive JK, Nguyen TC, Solinas M, Bianchi G. Ann Cardiothorac Surg. 2020 Sep;9(5):347-363. doi: 10.21037/acs-2020-surd-17. PMID: 33102174; PMCID: PMC7548209.
  8. Minimally Invasive vs Conventional Aortic Valve Replacement With Rapid-Deployment Bioprostheses. D’Onofrio A, Tessari C, Lorenzoni G, Cibin G, Martinelli G, Alamanni F, Polvani G, Solinas M, Massetti M, Merlo M, Vendramin I, Di Eusanio M, Mignosa C, Mangino D, Russo C, Rinaldi M, Pacini D, Salvador L, Antona C, Maselli D, De Paulis R, Luzi G, Alfieri O, De Filippo CM, Portoghese M, Musumeci F, Colli A, Gregori D, Gerosa G. Minimally Invasive vs Conventional Aortic Valve Replacement With Rapid-Deployment Bioprostheses. Ann Thorac Surg. 2021 Jun;111(6):1916-1922. doi: 10.1016/j.athoracsur.2020.06.150. Epub 2020 Oct 9. PMID: 33039363.Ann Thorac Surg. 2021 Jun;111(6):1916-1922.
  9. Minimally invasive access type related to outcomes of sutureless and rapid deployment valves. Andreas M, Berretta P, Solinas M, Santarpino G, Kappert U, Fiore A, Glauber M, Misfeld M, Savini C, Mikus E, Villa E, Phan K, Fischlein T, Meuris B, Martinelli G, Teoh K, Mignosa C, Shrestha M, Carrel TP, Yan T, Laufer G, Di Eusanio M. Eur J Cardiothorac Surg. 2020 Nov 1;58(5):1063-1071.
  10. Conduction disorders after aortic valve replacement: what is the real impact of sutureless and rapid deployment valves? Berretta P, Montecchiani L, Vagnarelli F, Cefarelli M, Alfonsi J, Zingaro C, Capestro F, Pierri MD, D’alfonso A, Di Eusanio M. Ann Cardiothorac Surg. 2020 Sep;9(5):386-395.
  11. Sutureless and rapid deployment implantation in bicuspid aortic valve: results from the sutureless and rapid-deployment aortic valve replacement international registry. Miceli A, Berretta P, Fiore A, Andreas M, Solinas M, Santarpino G, Kappert U, Misfeld M, Savini C, Albertini A, Villa E, Phan K, Fischlein T, Meuris B, Martinelli G, Teoh K, Mignosa C, Shrestha M, Carrel TP, Yan TD, Glauber M, Di Eusanio M. Ann Cardiothorac Surg. 2020 Jul;9(4):298-304.
  12. Current trends of sutureless and rapid deployment valves: an 11-year experience from the Sutureless and Rapid Deployment International Registry. Berretta P, Arzt S, Fiore A, Carrel TP, Misfeld M, Teoh K, Villa E, Albertini A, Fischlein T, Martinelli G, Shrestha M, Savini C, Miceli A, Santarpino G, Andreas M, Mignosa C, Phan K, Meuris B, Solinas M, Yan T, Di Eusanio M. Eur J Cardiothorac Surg. 2020 Nov 1;58(5):1054-1062.
  13. Minimally Invasive Redo Aortic Valve Replacement: Results From a Multicentric Registry (SURD-IR). Santarpino G., Berretta P., Kappert U., Teoh K., Mignosa C., Meuris B., Villa E., Albertini A., Carrel T. P., Misfeld M., Martinelli G., Phan K., Miceli A., Folliguet T., Shrestha M., Solinas M., Andreas M., Savini C., Yan T., Fischlein T., Di Eusanio M. (2020). ANNALS OF THORACIC SURGERY, ISSN: 0003-4975
  14. The sutureless and rapid-deployment aortic valve replacement international registry: lessons learned from more than 4,500 patients Di Eusanio M, Berretta P. Ann Cardiothorac Surg. 2020 Jul;9(4):289-297.
  15. Minimally invasive aortic valve replacement with sutureless and rapid deployment valves: a report from an international registry (Sutureless and Rapid Deployment International Registry)†.Berretta P, Andreas M, Carrel TP, Solinas M, Teoh K, Fischlein T, Santarpino G, Folliguet T, Villa E, Meuris B, Mignosa C, Martinelli G, Misfeld M, Glauber M, Kappert U, Savini C, Shrestha M, Phan K, Albertini A, Yan T, Di Eusanio M. Eur J Cardiothorac Surg. 2019 Oct 1;56(4):793-799.
  16. Operative outcome of patients at low, intermediate, high and “very high” surgical risk undergoing isolated aortic valve replacement with sutureless and rapid deployment prostheses: results of the SURD-IR registry. Santarpino G, Berretta P, Fischlein T, Carrel TP, Teoh K, et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 2019.
  17. Sutureless and Rapid-Deployment Aortic Valve Replacement International Registry (SURD-IR): early results from 3343 patients. Di Eusanio Marco, Phan Kevin, Berretta Paolo, Carrel Thierry P, Andreas Martin, Santarpino Giuseppe, et al. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 2018;54:768-773–773.
  18. Aortic valve replacement with sutureless and rapid deployment aortic valve prostheses. Berretta Paolo, Di Eusanio Marco. JOURNAL OF GERIATRIC CARDIOLOGY 2016;13:504–10.
  19. Sutureless aortic valve replacement: a systematic review and meta-analysis. Phan Kevin, Tsai Yi-Chin, Niranjan Nithya, Bouchard Denis, Carrel Thierry P, Dapunt Otto E, et al. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:100–11. doi:10.3978/j.issn.2225-319X.2014.06.01.
  20. In the era of the valve-in-valve: is transcatheter aortic valve implantation (TAVI) in sutureless valves feasible? Di Eusanio M, Saia F, Pellicciari G, Phan Kevin, Ferlito M, Dall’Ara G, et al. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:214–7.
  21. Sutureless Aortic Valve Replacement International Registry (SU-AVR-IR): design and rationale from the International Valvular Surgery Study Group (IVSSG). Di Eusanio Marco, Phan Kevin, Bouchard Denis, Carrel Thierry P, Dapunt Otto E, Di Bartolomeo Roberto, et al. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:131–9.
  22. Sutureless aortic valve replacement. Di Eusanio Marco, Phan Kevin. ANNALS OF CARDIOTHORACIC SURGERY 2015;4:123–30.

Hybrid Aortic Program:

  1. Frozen elephant trunk in normothermia without circulatory arrest: initial experience. Berretta P, D’Alessio S, Malvindi PG, D’Alfonso A, Cefarelli M, Galeazzi M, Bifulco O, Giusti M, Vento V, Spagnolo F, Gatta E, Di Eusanio M. Ann Cardiothorac Surg. 2025 Jul 31;14(4):291-302.
  2. Normothermic frozen elephant trunk without circulatory arrest. Berretta P, Galeazzi M, Malvindi PG, Bifulco O, Buratto B, Cefarelli M, Alfonsi J, Capestro F, Gatta E, Di Eusanio M. Indian J Thorac Cardiovasc Surg. 2023 Dec;39(Suppl 2):358-359.
  3. Normothermic frozen elephant trunk: our experience and literature review. Malvindi PG, Alfonsi J, Berretta P, Cefarelli M, Gatta E, Di Eusanio M. Cardiovasc Diagn Ther. 2022 Jun;12(3):262-271.
  4. Frozen Elephant Trunk Without Circulatory Arrest in Acute Aortic Dissection. Di Eusanio M, Gatta E. Ann Thorac Surg. 2021 Aug;112(2):e143-e145.
  5. Graft endoclamping with brachio-femoral wire conduit for elephant trunk retrieval in open thoraco-abdominal aortic repair. Gatta E, Berretta P, Carbonari L, Di Eusanio M. Eur J Cardiothorac Surg. 2020 Nov 16:ezaa358.
  6. Normothermic frozen elephant trunk surgery without circulatory arrest: how we do it in Ancona Di Eusanio M, Cefarelli M, Alfonsi J, Berretta P, Gatta E. Ann Cardiothorac Surg. 2020 May;9(3):244-245.
  7. Devices for thoracic endovascular aortic repair of type B aortic dissection: is there any chance for Marfan syndrome? Lovato L, Cefarelli M, Gatta E, Di Eusanio M, Fattori R. Expert Rev Med Devices. 2020 Jul;17(7):683-696.
  8. Arch Surgery for Type Ia Endoleak: How to Remain Normothermic and Avoid Circulatory Arrest. Di Eusanio M, Cefarelli M, Alfonsi J, Berretta P, Gatta E. Ann Thorac Surg. 2020 Aug;110(2):e139-e141.
  9. ‘Double layer’ frozen elephant trunk with balloon endoclamping: a technique to simplify the 2-stage open repair of thoraco-abdominal aortic aneurysms.Di Eusanio M, Berretta P, Cefarelli M, Gatta E. Eur J Cardiothorac Surg. 2020 Aug 1;58(2):389-391.
  10. Emergency Endovascular Treatment of Coral Reef Aorta with an Unconventional Technique. Emanuele Gatta , Paolo Berretta , Gabriele Pagliariccio , Sara Schiavon , Luciano Carbonari. Ann Vasc Surg. 2020 Feb;63:456.e5-456.e9.
  11. Treatment of a Proximal Giant Thoracic Aortic Aneurysm in Preview Open Repair of Thoracoabdominal Aortic Aneurysm, Sandwich Technique with Valiant Navion Evo Thoracic Endograft®.Gatta E, Berretta P, Pagliariccio G, Gironi G, Carbonari L. Ann Vasc Surg. 2019 Nov;61:468.e1-468.e3.

Catheter based interventions:

  1. Multimodality Imaging for Transcatheter Tricuspid Regurgitation Interventions: Novel Approaches to the Forgotten Valve. Coraducci F, Barbarossa A, Lofiego C, Vagnarelli F, Schicchi N, Fogante M, Piva T, Capestro F, Casella M, Di Eusanio M, Guerra F, Dello Russo A. Echocardiography. 2024 Dec;41(12):e70044.
  2. Transcatheter Mitral Valve Intervention: Current and Future Role of Multimodality Imaging for Device Selection and Periprocedural Guidance. Brugiatelli L, Rolando M, Lofiego C, Fogante M, Capodaglio I, Patani F, Tofoni P, Maurizi K, Nazziconi M, Massari A, Furlani G, Signore G, Esposto Pirani P, Schicchi N, Dello Russo A, Di Eusanio M, Vagnarelli F. Medicina (Kaunas). 2024 Jul 1;60(7):1082.
  3. Improved Early Outcomes in Women Undergoing Aortic Valve Interventions. Malvindi PG, Bifulco O, Berretta P, Alfonsi J, Cefarelli M, Zingaro C, Capestro F, D’Alfonso A, Di Eusanio M. J Clin Med. 2023 Sep 4;12(17):5749.
  4. Results and insights after 413 TAVI procedures performed by cardiac surgeons on their own. Malvindi PG, Berretta P, Capestro F, Bifulco O, Alfonsi J, Cefarelli M, Pierri MD, Di Eusanio M. Interdiscip Cardiovasc Thorac Surg. 2023 Jun 1;36(6):ivad074.
  5. Transcatheter cerebral embolic protection in open heart surgery: our initial experience in Ancona, Italy.Montecchiani L, Alfonsi J, Cefarelli M, Berretta P, Capestro F,: 10.1714/3455.34444.PMID: 33077996
  6. Catheter-based cerebral protection system in open cardiac surgery: An example of true hybrid surgery. Capestro F, Berretta P, Alfonsi J, Cefarelli M, Pierri M, Di Eusanio M. Multimed Man Cardiothorac Surg. 2020 Apr 22;2020.
  7. Minimally invasive aortic valve replacement with a catheter-based cerebral protection system: transferring percutaneous technologies into a surgical intervention. Di Eusanio M, Cefarelli M, Berretta P, Capestro F. Eur J Cardiothorac Surg. 2019 Nov 1;56(5):1016-1017.
  8. Early and mid-term results of the transapical aortic valve Symetis Acurate TA: a viable solution in high-risk patients with severe vascular disease. Rescigno Giuseppe, Fratesi Maria Giovanna, Aratari Carlo, Moretti Stefano, Capestro Filippo, Serenelli Massimiliano, et al. GIORNALE ITALIANO DI CARDIOLOGIA 2017;18:727–33.
  9. Transcatheter valve-in-valve implantation versus reoperative conventional aortic valve replacement: a systematic review. Phan Kevin, Zhao Dong-Fang, Wang Nelson, Huo Ya Ruth, Di Eusanio Marco, Yan Tristan D. JOURNAL OF THORACIC DISEASE 2016;8:E83-93.

Noema SRL unipersonale – via Orefici, 4
40124 – Bologna (Bo) – Cod.Fisc. e P.IVA 03809750379
Privacy policy

Noema SRL unipersonale – via Orefici, 4
40124 – Bologna (Bo) – Cod.Fisc. e P.IVA 03809750379
Privacy policy